Medicinal chemistry consulting
AKos consults across the full discovery workflow — from hit assessment to lead optimization and scaffold design.
Your partner in medicinal chemistry decisions
AKos brings scientific judgement where it makes the biggest difference — from hit triage through lead optimization and program strategy.
Independent scientific judgement
Unbiased chemistry input focused on the decisions that move your program forward.
Cross-program experience
Perspective from many discovery projects, target classes, and modalities.
Embedded collaboration
We plug into your design meetings and documentation with clear responsibilities.
How we support discovery programs
Six core capabilities where our medicinal chemistry engagements typically sit.
Compound prioritization
Ranking series and analogues against multi-parameter criteria to focus experimental effort.
Hit assessment
Rigorous triage of screening output — validation, artifact filtering and tractability scoring.
SAR analysis
Structured analysis of series behaviour to guide the next round of design decisions.
Lead optimization
Balanced optimization of potency, selectivity, DMPK and developability.
Scaffold design
Novel and IP-defensible scaffold ideas grounded in target biology and precedent.
Discovery strategy
Program-level input — modality choice, screening cascade design and go/no-go criteria.
How we work with your team
A clear cadence from scoping through decision support — sized to your program.
Scope & align
Define objectives, decision points, and how our chemists integrate with your team.
Iterate & decide
Join design meetings and support go/no-go decisions as the program advances.
Review & assess
Evaluate compounds, screening data, and SAR to surface risks and opportunities.
Design & recommend
Propose next-round analogues, scaffold options, and prioritization schemes.
Before You Engage Us
Common questions from partners considering a medicinal chemistry engagement.
- How is a consulting engagement structured?
- Engagements range from a single project review through recurring participation in your discovery meetings. We scope with you before starting and revise as the program evolves.
- Do you work as an integrated part of our team?
- Yes. Many engagements involve regular design meetings, shared documentation and joint decision-making — with clear boundaries on responsibilities.
- Can you support programs across therapeutic areas?
- Our expertise is medicinal chemistry — the principles carry across target classes. We're most active in oncology, immunology, neuroscience and metabolic disease, but we work where the chemistry demands it.
Let's Advance Your Discovery Program
Work with experienced medicinal chemists to evaluate compounds, define strategy, and accelerate better scientific decisions.